First responders said the blaze broke out at a home on the 3700 block of Tiffany Drive just before 4 a.m.
The fire reached a "partial-third" alarm and additional departments were called to the scene. Photos showed thick smoke clouds and flames reaching high above the roof.
A Nacy Run firefighter was treated for burns and two residents of the home were taken to a hospital for evaluation, authorities said.
Crews cleared the scene by around 7 a.m., they added.
Click here to follow Daily Voice Northampton and receive free news updates.
ncG1vNJzZmickZ65usLOopqeZpOkunC8xKelrLGcq66vtcBopaiqpJ2urrzTqKVooJ%2BisrDDzZ6prGWWnr%2Bmssign62domK1tr7TZqCnZZ2WwLS11Z5km52knbmmtMSmZK2voGK1sMHSnmSfoaKaerG0zq2mrGc%3D